What is Hair Regeneration?

An Alternative to Hair Transplant

Acell-PRP Case Studies

Hair Regeneration before and after
Hair Regeneration non-surgical treatment dramatically thickens a young male patient’s hair. No surgery was performed. Patient was previously taking finasteride (Propecia) which he didn’t respond to.

Hair Regeneration is a non-surgical treatment for thinning hair and hair loss hair that makes use of adult stem cell based wound-healing properties developed by hair restoration specialist, Dr. Amiya Prasad, MD.Dr. Prasad’s Hair Regeneration is customized in terms of concentrations, areas treated, depth of treatment and technique. The materials used for Dr. Prasad’s Hair Regeneration treatment include:

Extracellular Matrix (ECM)  — a wound healing material that attracts increased blood supply and adult stem cells, which duplicates human tissue like skin and muscle. When used in treating hair loss, ECM appears to clinically restore the necessary cells (progenitor cells) responsible for healthy hair growth.

Platelet-Rich Plasma (PRP) — the isolated serum derived from a patient’s own blood which contains regenerative healing and growth factors. PRP is used in regenerative medicine applications in oral surgery, orthopedic surgery and cosmetic surgery.

Vitamin D — the nutrient, demonstrated by University of Tokyo, to increase transformation of cells in tissue culture to transplantable hair follicles.

Other materials customized to the patient’s cause of hair loss such as anti-inflammatory medication.

How Does Hair Regeneration Work

Wound Healing Concept
Platelet-rich plasma (PRP) and extracellular matrix (ECM) is injected into the scalp for a wound healing response that activates adult stem cells. Slowed hair growth that leads to thinning is renewed, so hair thinning is reversed and hair grows progressively thicker.

Dr. Amiya Prasad’s Hair Regeneration treatment is a quick, non-surgical and lasting solution to hair loss that reactivates existing hair follicles and jumpstarts the normal hair growth cycle through a combination of platelet-rich plasma (derived from the patient) and an extracellular matrix. It is designed to reverse the hair thinning cycle and subsequently stops continued hair loss.

Hair loss occurs when the presence of DHT (dihydrotestosterone) disrupts the line of communication between the dermal papilla, which is located at the root of the hair follicle, and the progenitor cells, which is a type of adult stem cell responsible for healthy hair growth. Dr. Amiya Prasad’s Hair Regeneration system is designed to restore these communication lines and reverse the thinning effect that DHT has on hair.

Dr. Amiya Prasad’s Hair Regeneration treatment mix is delivered via injection directly into the scalp. This triggers a wound-healing response in the body and attracts an increased supply of blood and adult stem cells, which in turn, increases the production of progenitor cells in the area. Thus, hair that was previously thinning and weak grows progressively thicker and stronger.

Upon reviewing treatment data, Dr. Amiya Prasad’s Hair Regeneration treatment has shown to be effective in 99% of male pattern hair loss patients and about 80% of female pattern hair loss patients. After reviewing 5 years of clinical data, results have shown that only a single treatment is all that is needed, although Dr. Prasad has been performing second treatments in select patients.

Hair Regeneration Treatment and Hair Transplants

Dr. Amiya Prasad’s Hair Regeneration treatment is so effective in thickening hair that many people who undergo the treatment often feel that they don’t need to undergo an additional hair transplant. However, for patients who do opt for a hair transplant, the Hair Regeneration treatment has shown to help increase the success rate of hair transplant surgery in the following ways:

Improving survival rate of hair transplant grafts. The Hair Regeneration system’s wound healing components improves the healing rate of transplanted hair follicles, thereby increasing the survival rate of transplanted hair grafts.

Thickening hair that was previously thinning. The Hair Regeneration system can reverse progressive, future hair loss — an important issue that hair transplants alone do not address.

Improving donor area healing. The combination of wound-healing materials in Hair Regeneration can be used to help the healing process of the donor area scar at the back of the head from follicular unit transplantation (FUT), as well as follicular unit extraction (FUE).

hair-regeneration-before-and-afters-045

What Is ACell’s Extracellular Matrix (ECM)?

ACell vial imageACell’s patented Extracellular Matrix (ECM) products are covered by multiple 510(k) clearances and address important unmet clinical needs, providing safe, effective and therapeutic outcomes.

Derived from porcine urinary bladders and referred to as UBM (urinary bladder matrix), trademarked as MatriStem™, ACell’s core technology is a naturally occurring, non-crosslinked, completely resorbable acellular biomaterial.

A similar “first generation” ECM technology has been used to treat over 500,000 patients with remarkable effect. ACell’s MatriStem products are the next generation of ECM technology due to its unique characteristics featuring a basement membrane surface which is ideal for epithelial cell growth in many applications.

How does ACell’s Extracellular Matrix Work?

Extracellular matrix (ECM), produced by ACell, is the by-product of urinary bladder tissue that has proven regenerative properties. The product is stripped of all cells, as well as muscle tissue, to prevent graft versus host reactions (allergic reactions) when introduced in humans.

The way ACell’s ECM works in wound healing is by recruiting adult stem cells, along with an increased blood supply, to the sight of a wound. It then effectively changes these inactive adult stem cells back into progenitor cells (its active form) and facilitates direct healing by duplicating native tissue instead of scar tissue.

ACell’s ECM also provides growth factors and proteins necessary for tissue regeneration, and also sets up a temporary non-crosslinked scaffolding for the tissue reconstruction mimicking the surrounding healthy but damaged tissue. This scaffolding contains and slowly releases growth factors (VEGF etc.). The scaffold is metabolized allowing the healing and regeneration to be carried out by one’s own cells and tissue.

Why Extracellular Matrix for Hair Restoration?

Extracellular matrix is unique as it is bi-modal and contains a basement membrane necessary to attract and propagate 

 

Preparation of the PRP
Preparation of the PRP

 

both epithelial and endothelial cells. Extracellular matrix works by setting up a temporary cellular scaffold or bridge, and then attracts massive blood supply and adult stem cells. A large number of inactive adult stem cells continue to circulate in the human body in after we are born. The stem cells are attracted to the site of injury, where they are converted back into progenitor cells.

Extracellular matrix also contains a considerable amount of the necessary proteins and growth factors to reconstruct and copy tissue, along with nerves and appendages (hair for example). PRP also contains a large number of adult stem cells.



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