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Cure For Baldness? Mouse Study Shows Human Hair Regrowth From Stem Cells

No, it’s not the mouse version of a Mohawk. These creatures, the subjects of a new study, were implanted with follicles made from human cells, which soon took root and grew normally.

Only slightly less creepy than this mouse with human ear cells on its back, the animals would even grow their new hairs back if they were plucked out.

The team that conducted the research came from universities across Japan, and was led by Dr. Takashi Tsuji, a professor at the Research Institute for Science and Technology at Tokyo University of Science (TUS).

Dr. Tsuji’s lab at TUS specializes in cutting-edge regenerative medicine, and was also responsible for the 2011 experiments that used stem cells to regrow a tooth in a mouse’s mouth.

As for the new research, Dr. Tsuji told the Associated Press, “At this point, this kind of precise cellular operation is only possible by our team.”

Hair Transplantation and Regeneration

To produce the cells the scientists implanted in the mice, they had to make the hair follicles from scratch, mixing two different types of cell to create a “seed” follicle— they created these seed cells from mouse embryos, adult mice and finally adult humans.

The rats in the photos below demonstrate human hair growth, an exciting prospect for researchers hoping to treat baldness in people.

But don’t toss out your Rogaine yet. As ScienceNews.org noted, “these findings do not show whether the number of human hair follicles can be amplified, so that more hair is produced”— as it is, the hairs had to be implanted one at a time, which could be a much bigger job on a balding human than on a mouse.

Mouse Implanted with Follicles

Source: Huffington Post.

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Dr. Hitizig’s research published in the American Journal of Cosmetic Surgery

Dr. Hitzig’s research into the benefits of Hair Rescue Regrowth Injection therapy continues as he works with Dr. Prasad in their New York offices and in collaboration with hair restoration surgeons across the country and around the world.

In the first issue of 2012 – The American Journal of Cosmetic Surgery publishes Dr. Hitzig’s work and applications of ACell now known as Hair Rescue. The article titled: Use of Urinary Bladder Matrix, a Bioactive, Acellular Scaffold, in Transplant Donor Scars and Androgenetic Alopecia: Initial Clinical Experience, is details the basis on Dr. Hitzig’s work

Read Dr. Hitzig’s recent article published in the American Journal of Cosmetic Surgery on his research of ACell in wound healing and hair replication in hair transplant surgery.

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New discovery brings hope for balding men

Based on the headline and worldwide attention of this recent study Dr. Hitzig felt compelled to comment and clarify:


In reviewing the article below and associating it with Dr. Cotsarelis’s prior studies and those out of Yale University in Sept. 2011, it seems clear that the increase in Prostaglandin D2 Synthase occurs after the Stem Cells in the fatty layer of the scalp become faulty and stop producing the active Progenitor Cells necessary to protect the genetically sensitive hairs from DHT in the scalp.

Yes one can try to decrease the PD2 levels to theoretically “save” the hairs once the damage is being done, but it would make more sense to replenish the Progenitor cells first to prevent PD2 from exerting any negative effect (if that is what it is doing). We know from Propecia that decreasing 5DHT can slow down and even reverse hair loss in various cases. We now also know that Progenitor Cells act in both men and women (much like Estrogen in young women with genetic hair loss) to protect the hairs from miniaturizing. We have seen excellent results from the combination of ACell/Enhanced PRP which we employ in the Hair Rescue System to stop and often reverse hair loss. This is and should remain the first line of defense rather than damage control–the Hair Rescue results are exciting both in genetic alopecia and alopecia areata. … Dr. Gary S. Hitzig


Scientists have identified a hair-loss protein in a development that could pave the way for a cure for male-pattern baldness.

By Donna Bowater – The Daily Telegraph

The discovery could mean treatments are developed to suppress the protein and to stop baldness, although it would not reverse the effects to reverse hair loss.

Tests were carried out on tissue from the scalps of more than 20 men with male pattern baldness, known as androgenic alopecia (AGA).

The results showed bald areas had levels of the protein PGD2 three times higher than hairy areas.

There are already 10 drugs available that can block the receptor that allowed PGD2 to work, which could help researchers develop a treatment in the form of a cream or ointment.

The research, led by Professor George Cotsarelis from the University of Pennsylvania, was published in the journal Science Translational Medicine.

“Our findings should lead directly to new treatments for the most common cause of hair loss in men, AGA,” the team said.

“The potential for developing these compounds into topical formulations for treating AGA should elicit great interest moving forward.”

Professor Cotsarelis added: “Although a different prostaglandin was known to increase hair growth, our findings were unexpected, as prostaglandins haven’t been thought about in relation to hair loss, yet it made sense that there was an inhibitor of hair growth, based on our earlier work looking at hair follicle stem cells.”

Future studies are expected to investigate whether a protein inhibitor could also help women with AGA.

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ACell + PRP Hair Rescue in only 21 days!

25 year old male with advanced male pattern baldness (MPB) before Hair Rescue ACell Hair Regrowth Therapy and only 21 days after injection therapy. Click on image to see next photo.

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Dr. Hitzig Invited to Participate in International Congress of Italian Society of Hair Restoration in Rome

Dr. Gary Hitzig, a leading hair transplant surgeon, hair restoration researcher and founder of the Hair Rescue hair re-growth injection therapy, will moderate the session The Future of Hair Restoration and Regenerative Medicine at the 25th International Congress of Italian Society of Hair Restoration (ISHR) in Rome, Italy on May 24 – 27, 2012.The ISHR Congress attracts major national and international hair restoration surgeons from around the world. The purpose of the annual meeting is to present and discuss current hair restoration practices and explore new technologies in the field.Dr. Hitzig is known internationally as the pioneer of the ACell / platelet rich plasma (PRP) hair re-growth injection therapy, now called Hair Rescue. He spent years researching and proving that when the wound healing powder ACell MatriStem MicroMatrix is dissolved in a specialized blood serum rich in the patient’s adult stem cells and injected into the scalp, the combination acts like a hair growth accelerator..  
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ACell results from Oslo, Norway

Dr. Hitzig was invited to participate in a study in Oslo, Norway in August of 2011. The study was sponsored by Poseidon Clinic, one of the largest hair restoration practices in Europe. Among the patients treated with ACEll plus PRP were men and women experiencing genetic hair loss. Injection therapy and hair transplant surgery was performed by Dr.Kosmidis Charalampos, under the supervision of Dr. Hitizig, who provided ACell under special permission of the Norway government.

Below are photos of a mid-fifties femaie experiencing diffuse female genetic alopecia, post menopause. She was treaed with ACell plus PRP hair regrowth injection therapy, known as Hair Rescue. After photo was sent by Dr. Charalampos, 6 months after treatment. the patient had no hair transplant surgery. No other treatments were applied.

Female Patient treated with ACell + PRP Injections

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Winning The War on Hair Loss – How Two Doctors are Rescuing Hair with 21st Century “Hair Cloning”

AVENUE MAGAZINE – MARCH 2012

Drs. Gary Hitzig and Amiya Prasad

You’re losing hair. Looking into the mirror and seeing the hair you once took for granted disappear can be devastating. More than 50% of men are affected by hair loss. It affects 30% of women and approximately 50% of women after the age of 50.

Drugs such as Rogaine, Propecia and treatments such as hair lasers and hair transplants are a multi-billion dollar industry worldwide. When it comes to hair, “greed is good.”

Numerous psychological studies have shown that a full head of hair makes you look younger, energetic, and even more trustworthy. Having hair is a sign of strength and power. Unfortunately, drugs like Rogaine work only on some men and have limited benefits for women. Women can’t take Propecia. Recent concerns about sexual side effects have limited use of Propecia.

Hair transplant surgery has come a long way but the procedure still carries the stigma of the “pluggy look”. Dr. Gary Hitzig, a hair specialist for over 35 years, has developed the first successful “hair cloning” procedure which he and his partner, Upper Eastside Cosmetic Surgeon Dr. Amiya Prasad have named “Hair Rescue™.” Dr. Hitzig has developed a process using an FDA cleared material called “ACell” which activates your own adult stem cells. ACell is currently being used to help U.S. soldiers with major injuries and has even been shown to grow back an amputated finger- including the fingernail and the fingerprint!

Dr. Hitzig was the first hair specialist to investigate ACell after the FDA allowance for human use in 2008. Drs Hitzig and Prasad have developed systems of combining ACell with a concentrated part of the blood rich in growth factors called “platelet rich plasma” (PRP). This treatment uses the patients’ own platelets and combines them with the ACell, activating malfunctioning adult stem cells in areas of hair loss and rescuing thinning hair.

“In contrast to a surgical procedure, men and women with thinning hair can come in and have the treatment the way you do for Botox or Restylane”, comments Dr. Prasad. People have come for the treatment from all over the world from places such as Australia, Italy, India and New Zealand.

Does it last? “At this point, we haven’t had to repeat a treatment for 2 years. We treat our clients on an individual basis and customize their treatments. Keeping your hair from thinning further is in itself a success. Call it a ‘vaccine’ against hair loss.” explains Dr. Hitzig.

As Dr. Prasad discusses, “In a world where we are living longer, working longer, having children at a later age and participating in online dating, looking your best is more important than ever. We have made a major advance in the battle against hair loss. At this point, the only thing you have to lose . . . is hair.”

For more information call 212.265.8877 or visit www.HairRescueUS.com

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Hair Rescue™ Treatment Offers More Affordable and Non-Surgical Option for Restoring Hair

Hair loss can be a thing of the past thanks to an injection that can help further prevent and even reverse hair loss. Dr. Gary Hitzig is a leading hair restoration specialist and pioneer of the ACell / platelet rich plasma (PRP) injections, now called Hair Rescue™ injections. He has spent years researching and proving that only when the wound healing powder ACell MatriStem MicroMatrix is combined with PRP, in the proprietary formulation that he has developed over the course of his thorough research and clinical studies, it can help to both prevent and regenerate hair in men and women experiencing genetic hair loss – all without surgery.Dr. Hitzig discovered that if the MatriStem powder is dissolved in a specialized blood serum rich in the patient’s adult stem cells and injected into the scalp, his proprietary combination acts like a hair growth accelerator. The Hair Rescue™ injection treatment is now available at Prasad Cosmetic Surgery and Medi-Spa through its newly opened Hair Rescue and Restoration™ center.“Hair Rescue injections finally give men and women a non-surgical option for both preserving and restoring hair by reactivating genetically faulty scalp stem cells,” said Dr. Hitzig. “For those in the early to moderate stages of hair loss, this revolutionary, proprietary injectable combination of ACell and PRP can help prevent further hair loss and help restore a patient’s hair.”Dr. Hitzig and partner, Dr. Amiya Prasad have been seeing patients from all around the world ever since Hitzig’s work with ACell and PRP gained world-wide attention in the field of hair restoration. Many patients see improvement in hair volume in as early as three weeks to six months following Hair Rescue™ injections in their scalp and in two years, not one patient has needed repeat injections, making this a much more affordable option for improving hair loss.
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Dr. Gary Hitzig discusses ACell Therapy with Cosmetic Surgery Today

Dr. Hitzig appears on Cosmetic Surgery Today.

They were so excited with Dr. Hitzigs’ results they wrote:

“Here’s an Inside Cosmetic Surgery first: a video! Take a look at this webinar interview we’ve done with Dr. Gary Hitzig, a board certified hair restoration specialist with Prasad Cosmetic Surgery.

Some of the results are so incredible, that you have to see it to believe it!

Dr. Hitzig walks us through the his hair restoration process, which includes the use of extracellular matrix technology (Acell) and platelet rich plasma (PRP), to promote cell duplication instead of scarring.”

View the webinar below.

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Video Presentation by Dr. Hitzig to ISHRS on ACell Research

Video Presentation by Dr. Hitzig to ISHRS on ACell Research19th Annual ISHRS Scientific Meeting – Anchorage (2011) – Presented on Friday/September 16, 2011, Dr. Gary Hitzig describes clinical applications of porcine urinary bladder matrix – UBM (i.e., ACell MatriStem). UBM is an extracellular matrix, FDA-approved wound healing agent being studied for its practical uses in hair restoration surgery. Use of this agent has been found to stimulate regenerative potential including angiogenesis and recruitment of stem cells.
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