Hair Regeneration by Dr Prasad

Dr. Amiya Prasad’s Hair Regeneration treatment is a quick, non-surgical  approach to hair loss using a customized system which includes combining platelet-rich plasma (derived from the patient) and an extracellular matrix (used for wound healing). The procedure appears to clinically reactivate hair that is not growing, strengthen existing hair and prolong to longevity of thinning hair. Hair loss treatment is not a one size fits all approach. Dr. Prasad customizes a treatment plan based on specific aspects of your hair loss including age of onset, rate of progression, degree of hair loss, response to previous therapies as well as information derived from physical examination.


Hair Regeneration for male pattern hairloss before and after 7 months

Acell-PRP Case Studies

 What is Hair Regeneration?

Hair Regeneration is a non-surgical treatment for thinning hair and hair loss hair that makes use of adult stem cell based wound-healing properties developed by hair restoration specialist, Dr. Amiya Prasad. Dr. Prasad’s Hair Regeneration is customized in terms of concentrations, areas treated, depth of treatment and technique. The materials used for Dr. Prasad’s Hair Regeneration treatment include:

  1. Extracellular Matrix (ECM)  — a wound healing material that attracts increased blood supply and adult stem cells, which duplicates human tissue like skin and muscle. When used in treating hair loss, ECM appears to clinically restore the necessary cells (progenitor cells) responsible for healthy hair growth.
  2. Platelet-Rich Plasma (PRP) — the isolated serum derived from a patient’s own blood which contains regenerative healing and growth factors. PRP is used in regenerative medicine applications in oral surgery, orthopedic surgery and cosmetic surgery.
  3. Vitamin D — the nutrient, demonstrated by University of Tokyo, to increase transformation of cells in tissue culture to transplantable hair follicles.

Other materials customized to the patient’s cause of hair loss such as anti-inflammatory medication.


How Does Hair Regeneration Work

The mechanism of how Hair Regeneration works has not been clearly defined as of yet. Platelet-rich plasma (PRP) and extracellular matrix (ECM) is injected into the scalp resulting in what appears to be a wound healing response from adult stem cells which results in the stimulation of hair growth and improvement in hair quality and longevity based on clinical observation.

Dr. Amiya Prasad’s Hair Regeneration treatment is a quick and non-surgical approach to managing hair loss which has become established as a viable option in the management of hair loss in men and women.

Wound Healing Concept illustration


Genetic pattern hair loss is not fully understood. One aspect of hair loss in men occurs when the presence of DHT (dihydrotestosterone) causes a process called “miniaturization” which is progressive hair thinning.

Genetic factors are responsible for 95%  of hair loss in men and women. 

Dr. Amiya Prasad’s Hair Regeneration treatment mix is delivered via injection directly into the scalp. This triggers a wound-healing response in the body and attracts an increased supply of blood and adult stem cells. The clinical observation is that hair that was previously thinning and weak grows progressively thicker and stronger.

Upon reviewing treatment data, Dr. Amiya Prasad’s Hair Regeneration treatment has shown to be effective in 99% of male and female pattern hair loss patients. This does not mean the procedure works with the same level on all patients. Individual characteristics such as age of onset, rate of progression and extent of hair loss are important variables in anticipating response and optimal treatment strategy.

Hair Regeneration treatment does not appear to have a direct effect on blood DHT level therefore, DHT blockers may be recommended as part of a treatment plan to maximize hair growth longevity in men.

Hair Regeneration Treatment and Hair Transplants

Dr. Amiya Prasad’s Hair Regeneration treatment can be so effective in thickening hair that many people who undergo the treatment often feel that they don’t need to undergo an additional hair transplant. However, for patients who do opt for a hair transplant, the Hair Regeneration treatment has shown to help increase the success rate of hair transplant surgery in the following ways:

  • Improving survival rate of hair transplant grafts. The Hair Regeneration system’s wound healing components improves the healing rate of transplanted hair follicles, thereby increasing the survival rate of transplanted hair grafts.
  • Thickening hair that was previously thinning. The Hair Regeneration system can reverse progressive, future hair loss — an important issue that hair transplants alone do not address.
  • Improving donor area healing. The combination of wound-healing materials in Hair Regeneration can be used to help the healing process of the donor area scar at the back of the head from follicular unit transplantation (FUT), as well as follicular unit extraction (FUE).

before and 6 months after hair regrowthhair regeneration before and after 6 months


What Is ACell’s Extracellular Matrix (ECM)?

ACell vial imageACell’s patented Extracellular Matrix (ECM) products are covered by multiple 510(k) clearances and address important unmet clinical needs, providing safe, effective and therapeutic outcomes.

Derived from porcine urinary bladders and referred to as UBM (urinary bladder matrix), trademarked as MatriStem™, ACell’s core technology is a naturally occurring, non-crosslinked, completely resorbable acellular biomaterial.

A similar “first generation” ECM technology has been used to treat over 500,000 patients with remarkable effect. ACell’s MatriStem products are the next generation of ECM technology due to its unique characteristics featuring a basement membrane surface which is ideal for epithelial cell growth in many applications.

How does ACell’s Extracellular Matrix Work?

Extracellular matrix (ECM), produced by ACell, is the by-product of porcine urinary bladder tissue that has proven regenerative properties. The product is stripped of all cells, as well as muscle tissue, to prevent graft versus host reactions (allergic reactions) when introduced in humans.

The way ACell’s ECM works in wound healing is by recruiting adult stem cells, along with an increased blood supply, to the sight of a wound. It then effectively changes these inactive adult stem cells back into progenitor cells (its active form) and facilitates direct healing by duplicating native tissue instead of scar tissue.

ACell’s ECM also provides growth factors and proteins necessary for tissue regeneration, and also sets up a temporary non-crosslinked scaffolding for the tissue reconstruction mimicking the surrounding healthy but damaged tissue. This scaffolding contains and slowly releases growth factors (VEGF etc.). The scaffold is metabolized allowing the healing and regeneration to be carried out by one’s own cells and tissue.

This wound healing response is theorized to benefit hair growth through several mechanisms which are not fully defined.

Why Extracellular Matrix for Hair Restoration?

Extracellular matrix is unique as it is bi-modal and contains a basement membrane necessary to attract and propagate 


Preparation of the PRP

Preparation of the PRP


both epithelial and endothelial cells. Extracellular matrix works by setting up a temporary cellular scaffold or bridge, and then attracts massive blood supply and adult stem cells. A large number of inactive adult stem cells continue to circulate in the human body in after we are born. The stem cells are attracted to the site of injury, where they are converted back into progenitor cells.

Extracellular matrix also contains a considerable amount of the necessary proteins and growth factors to reconstruct and copy tissue, along with nerves and appendages (hair for example). PRP also contains a large number of adult stem cells.

Hair Regeneration vs ACell+PRP Treatments?

Hair Regeneration is the original extracellular matrix (by ACell) and platelet-rich plasma treatment on the market. Hair Regeneration has been used on patients longer than any similar treatment, with clinical data going back over 5 years.

Hair Regeneration vs ACell+PRP Treatments?

If you look up ACell+PRP treatments, most practices don’t have a clear system in place to guide patients about expectations. Limited knowledge and experience results in a “shotgun” approach with patients having to come in frequently and pay as you go with no clear treatment strategy.

The first Hair Regeneration patients were treated over 5 years ago. The first Hair Regeneration patients had the treatment done with a hair transplant.

Shortly after using the Hair Regeneration treatment for hair transplant patients, Hair Regeneration was used as a standalone treatment, and a hair transplant alternative. With results of thicker hair, stopping progressive hair thinning and hair loss, and with hair density greater than any hair transplant, most Hair Regeneration patients choose not to undergo a hair transplant.

Experience derived from treating a wide range of patients and following their clinical responses for more than 7 years has resulted in Dr. Prasad being able to provide patients more knowledge about their individual clinical situation with a treatment plan strategy suited best for them.

Many ACell+PRP treatments are requiring several injections in the first year. Platelet-rich plasma on its own requires monthly injections with minimal effect. The vast majority of Hair Regeneration patients receive have received only one treatment to gain many of the results seen here. A second “booster” session is offered for many patients with moderate to severe hair loss at 15 to 18 months. Duration of benefit can be estimated based on your individual clinical profile determined during consultation.

Experience with many different types of hair loss is the basis of Dr. Prasad’s Hair Regeneration System. Dr. Prasad develops customized plans to minimize the number of injections while achieving optimal results.

Dr. Prasad worked for years to stabilize extracellular matrix in the Hair Regeneration formulation, and developed an algorithm so that even though the treatment is customized to each patient, effectiveness is still predictable.The main reason why many doctors cannot get ACell+PRP to last as long, and does not produce the same hair thickness as Hair Regeneration is that extracellular matrix by ACell is a very difficult material to work with and stabilize, especially when used in hair loss treatment.

Prior to using ACell’s extracellular matrix for healing hair transplant surgery, which led to Hair Regeneration, Dr. Prasad was already using extracellular matrix for cosmetic and reconstructive surgical healing. As a renowned full-body cosmetic surgeon, Dr. Prasad was using extracellular matrix for advanced healing of facelift incisions, reconstructive surgery, and tissue regeneration.

Dr. Prasad was one of the first cosmetic surgeons to adapt the use of platelet-rich plasma for cosmetic procedures. Originally used by oral and pediatric surgeons to increase blood supply to certain areas, Dr. Prasad was among the first cosmetic surgeons to embrace the wound healing and skin quality improvement benefits of platelet-rich plasma. He uses PRP extensively in improving thickness of thin eyelid skin, eyelid surgery healing , and skin quality improvement in anything from facial acne scars, deep tear troughs, and hand rejuvenation.

Patient Reviews on Hair Regeneration

Two years later, I am very pleased with the results and now sharing this amazing process with anyone who is willing to listen. Reviewer: walt.jI started Dr. Prasad treatment past 9 months. My hair started to regrow and more dense. Reviewer: svg380I feel like my hair loss has stopped and I am seeing stronger healthy hair. Reviewer: Jollenpatient review on hair regeneration procedurepatient review on hair loss treatment - After 10 months my hair is much thicker and not falling out. Reviewer name withheld
For hair restoration I would not consider anyone other than Dr. Prasad. I’m happy with my results and the entire experience overall. Reviewer: stevyraI saw a difference in my hair within a few months. Reviewer: R.F.patient review on ACell PRP hair loss treatment - I had the ACell + PRP injection procedure. I am pleased with my results. My hair is thicker and fuller. Reviewer: S RNow that I am 7 months into treatment, I can see lots of new hair growth and stronger hair. Reviewer name withheld

New York City Office